Pharaoh orders Hebrew boys killed
When the Hebrew midwives refused to kill newborn boys, Pharaoh commanded that every Hebrew son be thrown into the Nile.
Pharaoh commanded all his people, saying, “You shall cast every son who is born into the river, and every daughter you shall save alive.”
Exodus 1:22 (World English Bible)
The midwives Shiphrah and Puah feared God more than Pharaoh and let the boys live. God blessed them for it. Pharaoh then turned the whole nation into his executioners. It's the first of several times in Scripture that a ruler tried to wipe out God's people by killing their children; Herod's massacre at Bethlehem is another.
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Dating notes
Ussher places the decree between Aaron's birth (1574 BC) and Moses' birth (1571 BC), since Aaron apparently wasn't endangered. The exact year isn't given.